UBA1 CLIA Kit for Human(Homo sapiens) | EIAab.comUBA1 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > UBA1(Gene name) > Human

UBA1 (Gene name),

Ubiquitin-like modifier-activating enzyme 1 (Protein name ), UBA1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

UBA1(A1S9T;UBE1);

Protein name:

Ubiquitin-like modifier-activating enzyme 1;

Alternative:

Ubiquitin-activating enzyme E1;Protein A1S9;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer (By similarity). Interacts with GAN (via BTB domain).

Function:

Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

1058

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1058:

PYVRYTIR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00899

MIM:

301830

KEGG:

hsa:7317

String:

P22314

STRING:

9606.ENSP00000338413

UniGene:

Hs.533273

SMR:

P22314

Uniprot:

P22314

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ELISA Kit for Human Ubiquitin-like modifier-activating enzyme 1

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E12404h

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ELISA Kit for Human Ubiquitin-like modifier-activating enzyme 1

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ELISA Kit for Human Ubiquitin-like modifier-activating enzyme 1

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E12404r

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96T

ELISA Kit for Human Ubiquitin-like modifier-activating enzyme 1

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E12404b

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96T

ELISA Kit for Human Ubiquitin-like modifier-activating enzyme 1

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E12404m

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96T

CLIA Kit for Human Ubiquitin-like modifier-activating enzyme 1

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U12404h

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96T

CLIA Kit for Human Ubiquitin-like modifier-activating enzyme 1

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U12404b

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96T

CLIA Kit for Human Ubiquitin-like modifier-activating enzyme 1

Cat.:

U12404m

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MSDS:

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Packing:

96T

CLIA Kit for Human Ubiquitin-like modifier-activating enzyme 1

MSDS:

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CLIA Kit for Human Ubiquitin-like modifier-activating enzyme 1

Cat.:

U12404r

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96T

Polyclonal Antibody for Human Ubiquitin-like modifier-activating enzyme 1

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P12404Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Ubiquitin-like modifier-activating enzyme 1

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P12404Rb-h

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Polyclonal Antibody for Human Ubiquitin-like modifier-activating enzyme 1

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P12404Rb-r

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Polyclonal Antibody for Human Ubiquitin-like modifier-activating enzyme 1

Monoclonal Antibody for Human Ubiquitin-like modifier-activating enzyme 1

Protein for Human Ubiquitin-like modifier-activating enzyme 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Complementation by a cloned human ubiquitin-activating enzyme E1 of the S-phase-arrested mouse FM3A cell mutant with thermolabile E1."
Ayusawa D. , Kaneda S. , Itoh Y. , Yasuda H. , Murakami Y. , Sugasawa K. , Hanaoka F. , Seno T.
Cell Struct. Funct.17:113-122(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1."
Handley P.M. , Mueckler M. , Siegel N.R. , Ciechanover A. , Schwartz A.L.
Proc. Natl. Acad. Sci. U.S.A.88:258-262(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 136-158; 369-383; 417-430 AND 559-580
tissue: Placenta.
3.

Handley P.M. , Mueckler M. , Siegel N.R. , Ciechanover A. , Schwartz A.L.
Proc. Natl. Acad. Sci. U.S.A.88:7456-7456(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
4.

"The DNA sequence of the human X chromosome."
Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lymph.
7.

"Molecular cloning, primary structure and expression of the human X linked A1S9 gene cDNA which complements the ts A1S9 mouse L cell defect in DNA replication."
Zacksenhaus E. , Sheinin R.
EMBO J.9:2923-2929(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 257-989
8.

Lubec G. , Vishwanath V.
Submitted (2007-03) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 559-581 AND 924-944;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Brain.
tissue: Cajal-Retzius cell.
9.

"Isoforms of mammalian ubiquitin-activating enzyme."
Cook J.C. , Chock P.B.
J. Biol. Chem.267:24315-24321(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
10.

"Immunoelectron microscopic localization of the ubiquitin-activating enzyme E1 in HepG2 cells."
Schwartz A.L. , Trausch J.S. , Ciechanover A. , Slot J.W. , Geuze H.
Proc. Natl. Acad. Sci. U.S.A.89:5542-5546(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
11.

"Human ubiquitin-activating enzyme, E1. Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs."
Handley-Gearhart P.M. , Stephen A.G. , Trausch-Azar J.S. , Ciechanover A. , Schwartz A.L.
J. Biol. Chem.269:33171-33178(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;CHARACTERIZATION OF ISOFORM 1 AND ISOFORM 2
12.

"Identification of a region within the ubiquitin-activating enzyme required for nuclear targeting and phosphorylation."
Stephen A.G. , Trausch-Azar J.S. , Handley-Gearhart P.M. , Ciechanover A. , Schwartz A.L.
J. Biol. Chem.272:10895-10903(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-4;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-4 AND 8-LYS--ARG-11
13.

"Proteomic identification of proteins conjugated to ISG15 in mouse and human cells."
Giannakopoulos N.V. , Luo J.K. , Papov V. , Zou W. , Lenschow D.J. , Jacobs B.S. , Borden E.C. , Li J. , Virgin H.W. , Zhang D.E.
Biochem. Biophys. Res. Commun.336:496-506(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISGYLATION
14.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival."
Allen E. , Ding J. , Wang W. , Pramanik S. , Chou J. , Yau V. , Yang Y.
Nature438:224-228(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GAN
16.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-46; THR-800 AND SER-835;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46 AND SER-810;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
19.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-671 AND LYS-980;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46 AND SER-810;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
21.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage."
Moudry P. , Lukas C. , Macurek L. , Hanzlikova H. , Hodny Z. , Lukas J. , Bartek J.
Cell Cycle11:1573-1582(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION
24.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
25.

"Rare missense and synonymous variants in UBE1 are associated with X-linked infantile spinal muscular atrophy."
Ramser J. , Ahearn M.E. , Lenski C. , Yariz K.O. , Hellebrand H. , von Rhein M. , Clark R.D. , Schmutzler R.K. , Lichtner P. , Hoffman E.P. , Meindl A. , Baumbach-Reardon L.
Am. J. Hum. Genet.82:188-193(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SMAX2 ILE-539 AND GLY-547
26.

"Clinical and neuropathological features of X-linked spinal muscular atrophy (SMAX2) associated with a novel mutation in the UBA1 gene."
Dlamini N. , Josifova D.J. , Paine S.M. , Wraige E. , Pitt M. , Murphy A.J. , King A. , Buk S. , Smith F. , Abbs S. , Sewry C. , Jacques T.S. , Jungbluth H.
Neuromuscul. Disord.23:391-398(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SMAX2 VAL-557

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